According to the environment of disease genes pattern, we from environmental and genetic two aspects to discuss this problem: first of all, from the environmental view, China's han Chinese living environment of may and the Caucasus person is different. The air pollution of suspended particles, will affect to many diseases, there are reports that China's pollution is serious neighboring countries, and heavy pollution will add to the body of the students oxidatie stress reaction, at present the influence of air pollution on AR remains uncertain, also recently about air pollution to the influence of AR, reported the automobile exhaust tips from the burning of coal produced with NO2 SO2 and CHR negative AR the onset of a significant association. Reports of the front of the positive people smoking mainly for the developed countries of the Caucasian, in some of China's industrial cities, air pollution obviously than developed countries more serious, if air pollution effects on the body and smoking something in common, it might be is the role of the individual environment cover up the role of smoking; Another possible reason is that although han Chinese female smokers less, but a high proportion of male smokers, in a living space is not large families, although women don't smoke, but men may be smoking, so our women may exist passive smoking.