记忆cd8 t细胞和细胞毒性cd8t细胞的区别

2025-03-28 10:20:58
推荐回答(2个)
回答(1):

总t淋巴细胞高,总B淋巴细胞高,抑制/细胞毒性T细胞数CD8

T淋巴细胞及亚群检测结解释些疾病发病机理、患者免疫功能预做判断及指导治疗些疾病主要包括:1.病毒染性疾病;2.肿瘤性疾病;3.自身免疫性疾病;4.器官移植患者;5.其免疫缺陷或异患者温州医科附属第二医院呼吸内科苏苗赏

淋巴细胞白细胞非重要类主要参与细胞免疫T淋巴细胞(CD3+)主要参与体液免疫B淋巴细胞(CD19+)T淋巴细胞辅助性T淋巴细胞(CD3+CD4+)抑制性/细胞毒性T淋巴细胞(CD3+CD8+)情况各群淋巴细胞数目相比例都定范围内

回答(2):

T细胞相复杂均体、断体内更新、同间存同发育阶段或功能
T淋巴细胞
亚群类原则命名比较混乱尚未统按免疫应答功能同T细胞若干亚群致公认:
辅助性T细胞(Helper T cells,Th)具协助体液免疫细胞免疫功能;
抑制性T细胞(Suppressor T cells,Ts)具抑制细胞免疫及体液免疫功能;
效应T细胞(Effector T cells,Te)具释放淋巴功能;
细胞毒性T细胞(Cytotoxic T cells,Tc)具杀伤靶细胞功能;
迟发性变态反应T细胞(Delayed type hypersensitivityT cells,Td)参与Ⅳ型变态反应作用;放T细胞(Ta)作用于ThTs扩免疫效作用;
原始或T细胞(Virgin or Natural T cells)抗原接触化效应T细胞记忆T细胞;
记忆T细胞(Memory T cell,Tm)记忆特异性抗原刺激作用T细胞体内存间数月至数其记忆细胞存间则更
其Th细胞称CD4+细胞其表面表达CD4(cluster of differentiation 4)通与MHCⅡ(主要组织相容性复合体major histocompatibility complex)递呈肽抗原反应激MHCⅡ抗原递呈细胞(antigen presenting cells,APCs)表面表达旦激泌细胞调节或者协助免疫反应Tc细胞名CD8+细胞其表面表达CD8.类细胞通MHCI 与抗原直接结合
流式细胞析仪FCM根据淋巴细胞表面标志同检测各淋巴细胞亚群:
淋巴细胞主要包括T淋巴细胞(CD3+)B淋巴细胞(CD19+)NK细胞(CD16+CD56+)
T淋巴细胞
其T淋巴细胞进步测定辅助/诱导T淋巴细胞(CD3+CD4+)、抑制/细胞毒T淋巴细胞(CD3+CD8+)、CD4+T细胞纯真亚群(CD4+CD45RA+/ CD4+CD45RA+62L+)记忆亚群(CD4+CD45RA-/ CD4+CD45RO+)、功能亚群(CD28+)、激亚群(CD38+、HLA-DR+)、凋亡亚群(CD95+)等
T细胞按照功能表面标志种类:
1、细胞毒T细胞(cytotoxic T cell):消灭受染细胞些细胞功能像杀手或细胞毒素产特殊抗原反应目标细胞进行杀灭细胞毒T细胞主要表面标志CD8称杀手T细胞
2、辅助T细胞(helper T cell)免疫反应扮演间程角色:增扩散激其类型产直接免疫反应免疫细胞辅助T细胞主要表面标志CD4 T细胞调控或辅助其淋巴细胞发挥功能已知HIV目标细胞艾滋病发病急剧减少
3、调节/抑制T细胞(regulatory/suppressor T cell):负责调节机体免疫反应通起着维持自身耐受避免免疫反应度损伤机体重要作用调节/抑制T细胞种目前研究跃CD25+ CD4+ T细胞
4、记忆T细胞 (memory T cell):再免疫应答起重要作用暂没发现记忆T细胞表面存非特异表面标志物相信随着研究深入记忆T细胞更深入解

T细胞淋巴细胞主要组具种物功能直接杀伤靶细胞辅助或抑制B细胞产抗体特异性抗原促丝裂原应答反应及产细胞等身体抵御疾病染、肿瘤形英勇斗士T细胞产免疫应答细胞免疫细胞免疫效应形式主要两种:与靶细胞特异性结合破坏靶细胞膜直接杀伤靶细胞;另种释放淋巴终使免疫效应扩增强
T细胞由胸腺内淋巴干细胞化淋巴细胞数量功能复杂类细胞按其功能三亚群:辅助性T细胞、抑制性T细胞细胞毒性T细胞功能类抵御疾病非重要目前止关T细胞演化及与癌症研究取少进展特别21世纪初类始命舟计划于T细胞演化及与癌症研究更取突破性进展
造血干细胞称能干细胞存于造血组织群原始造血细胞其特点能自身复制化通处于静止期机体需要裂增殖部化定向干细胞受定激素刺激进步化各系统血细胞系其淋巴干细胞进步化两条途径些干细胞迁移胸腺内胸腺激素影响量增殖化熟淋巴细胞亚群称T淋巴细胞T细胞T字采用胸腺拉丁文第字母命名第二细胞群类似氏囊器官或组织内受激素作用熟并化淋巴细胞另亚群称B淋巴细胞B细胞B字采用囊拉丁文第字母命名氏囊鸟类特结构位于泄殖腔囊壁充满淋巴组织哺乳物氏囊其类似结构能骨髓或肠道淋巴组织(集合淋巴结阑尾等)亦氏囊作用
T细胞产抗体直接起作用所T细胞免疫作用叫作细胞免疫B细胞通产抗体起作用抗体存于体液所B细胞免疫作用叫作体液免疫数抗原物质刺激B细胞形抗体程;需T细胞协助某些情况T细胞亦抑制B细胞作用抑制性T细胞受染、辐射、胸腺功能紊乱等素影响功能降低B细胞失T细胞控制功能亢进能产量自身抗体并引起各种自身免疫病例系统性红斑狼疮慢性性肝炎、类风湿性关节炎等同某些情况B细胞控制或增强T细胞功能由见身体各类免疫反应论细胞免疫体液免液共同构极精细、复杂完善防卫体系

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