【 abstract 】 objective to community based on the prospective follow-up cohort of antihypertensive treatment, observation of Beijing step-down 0 antihypertensive effect and adverse reaction, as well as the influence on blood lipid and biochemical indexes such as, provide scientific basis for scientific and reasonable using step-down 0. Method based on chronic disease prevention and control system of nanjing, with a new diagnosis of hypertension patients as the research object, according to the doctor's advice and the patient's own needs, it can be divided into Beijing step-down 0 group and conventional treatment group, prospectie cohort study, follow-up and detect the blood pressure, blood biochemical indices and record adverse reactions, such as queue follow-up until the end of December 2012.
Results Beijing step-down 0 group and routine treatment group, 390 and 392 respectively to complete follow-up treatment time is 2.17 years on average. Two groups of antihypertensive effectiveness were 94.9% and 97.4% respectively, both no statistical differences (chi-square = 3.52, P = 3.52). Two groups of adverse drug reactions occurred number 6 and 2, respectively, also no statistical difference (chi-square = 2.04, P = 2.04). Two groups of total cholesterol, triglyceride, aspertate aminotransferase, alanine aminotransferase, serum uric acid and fasting glucose at the end of the follow-up also no statistical difference (P value were greater than 0.05). Conclusion based on the prospective cohort study was to observe, and regular treatment with the Beijing step-down 0 similar antihypertensive effect and safety of the blood biochemical indexes, especially no adverse effect on blood uric acid metabolism.
求采纳